Inhibitors of the Arachidonate Cascade from Allium chinense and Their Effect on in Vitro Platelet Aggregation

YUKIHIRO GODA; MASAAKI SHIBUYA; USHIO SANKAWA

doi:10.1248/cpb.35.2668

Inhibitors of the Arachidonate Cascade from Allium chinense and Their Effect on in Vitro Platelet Aggregation

YUKIHIRO GODA, MASAAKI SHIBUYA, USHIO SANKAWA

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Keywords: Allium chinense, phenolic amide, N- (p-trans-coumaroyl) tyramine, N- (p-cis-coumaroyl) tyramine, stilbene, lunularic acid, p-coumaric acid, prostaglandin synthetase inhibitor, thromboxane synthetase inhibitor, platelet aggregation inhibitor

JOURNAL FREE ACCESS

1987 Volume 35 Issue 7 Pages 2668-2674

DOI https://doi.org/10.1248/cpb.35.2668

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Abstract

N- (p-trans-Coumaroyl) -and N- (p-cis-coumaroyl) tyramines (1, 2), lunularic acid (3) and p-coumaric acid (4), which are inhibitors of prostaglandin (PG) and thromboxane synthetases, were isolated from the bulb of Allium chinense G. DON, a Chinese medicinal drug. Stilbene derivatives structurally related to lunularic acid (3) were tested for inhibitory effect on prostaglandin synthetase. The compounds that inhibited PG biosynthesis also showed significant inhibitory effects on platelet aggregation induced by arachidonic acid and collagen.

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