Circular Dichroism Studies on the Ellagitannins-Nucleic Acids Interaction

NOBUKO KAKIUCHI; XUAN WANG; MASAO HATTORI; TAKUO OKUDA; TSUNEO NAMBA

doi:10.1248/cpb.35.2875

NOBUKO KAKIUCHI, XUAN WANG, MASAO HATTORI, TAKUO OKUDA, TSUNEO NAMBA

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Keywords: ellagitannin, dimeric ellagitannin, homopolynucleotide complex, nucleotidetannin interaction, CD, thermal denaturation temperature

JOURNAL FREE ACCESS

1987 Volume 35 Issue 7 Pages 2875-2879

DOI https://doi.org/10.1248/cpb.35.2875

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Abstract

The interaction of homopolynucleotides complexes and ellagitannins was studied by circular dichroism (CD) spectroscopy. The interaction difference CD spectra of mixtures of (rC)_n (dG)_n and dimeric ellagitannins showed extremely large positive peaks especially around 250 nm, suggesting a strong interaction. The mixtures with (rA)_n (dT)_n also had large difference CD spectra, although the interaction showed no apparent contribution to the stabilities of the nucleotides complexes.

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