Studies on Synthesis of 3-Ο-Alkyl-D-glucose and 3-Ο-Alkyl-D-allose Derivatives and Their Biological Activities

TETSURO IKEKAWA; KAZUHIKO IRINODA; KOICHI SAZE; TATSUHIKO KATORI; HIDEAKI MATSUDA; MASANORI OHKAWA; MARTIN KOSIK

doi:10.1248/cpb.35.2894

TETSURO IKEKAWA, KAZUHIKO IRINODA, KOICHI SAZE, TATSUHIKO KATORI, HIDEAKI MATSUDA, MASANORI OHKAWA, MARTIN KOSIK

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Keywords: Ο-alkyl glucose, Ο-alkyl allose, antitumor activity, cytotoxicity, plant growthinhibitory activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 7 Pages 2894-2899

DOI https://doi.org/10.1248/cpb.35.2894

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Abstract

Twenty two 3-Ο-alkyl derivatives of D-glucose and D-allose, four 3-Ο-alkenyl derivatives of D-glucose having an end methylene group, and four 3-Ο-ω-hydroxyalkyl- or -methoxyalkyl derivatives of D-glucose were synthesized. Their cytotoxicity in vitro against the cultured leukemia L-5178Y cell line, antimicrobial activity and plant growth-inhibitory effect were determined.

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