Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
New Laxative Constituents of Rhubarb. Isolation and Characterization of Rheinosides A, B, C and D
TAKASHI YAMAGISHIMAKOTO NISHIZAWAMITSUHIKO IKURAKUNIO HIKICHIGEN-ICHIRO NONAKAITSUO NISHIOKA
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1987 Volume 35 Issue 8 Pages 3132-3138

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Abstract

Four new laxative constituents, rheinosides A, B, C and D, were isolated from commercial rhubarb (Rhei Rhizoma). On the basis of high-resolution nuclear magnetic resonance spectral data and chemical correlation with rhein, the structures were characterized as stereoisomers of 8-O-β-D-glucosyl-10-hydroxy-10-C-β-D-glucosyl rhein-9-anthrone (rheinosides A and B), and 8-O-β-D-glucosyl-10-C-β-D-glucosyl rhein-9-anthrone (rheinosides C and D).

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