New Laxative Constituents of Rhubarb. Isolation and Characterization of Rheinosides A, B, C and D

TAKASHI YAMAGISHI; MAKOTO NISHIZAWA; MITSUHIKO IKURA; KUNIO HIKICHI; GEN-ICHIRO NONAKA; ITSUO NISHIOKA

doi:10.1248/cpb.35.3132

TAKASHI YAMAGISHI, MAKOTO NISHIZAWA, MITSUHIKO IKURA, KUNIO HIKICHI, GEN-ICHIRO NONAKA, ITSUO NISHIOKA

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Keywords: rhubarb, Rhei Rhizoma, Polygonaceae, rheinoside, C-glucosyl anthrone, rhein anthrone, laxative activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 8 Pages 3132-3138

DOI https://doi.org/10.1248/cpb.35.3132

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Abstract

Four new laxative constituents, rheinosides A, B, C and D, were isolated from commercial rhubarb (Rhei Rhizoma). On the basis of high-resolution nuclear magnetic resonance spectral data and chemical correlation with rhein, the structures were characterized as stereoisomers of 8-O-β-D-glucosyl-10-hydroxy-10-C-β-D-glucosyl rhein-9-anthrone (rheinosides A and B), and 8-O-β-D-glucosyl-10-C-β-D-glucosyl rhein-9-anthrone (rheinosides C and D).

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