Effect of the Molecular Weight of Polyethylene Glycol on the Bioavailability of Indomethacin Sustained-Release Suppositories Prepared with Solid Dispersions

NORIAKI OHNISHI; YOSHIFUMI KIYOHARA; YOSHIAKI KITA; KOJI KURODA; TERUYOSHI YOKOYAMA

doi:10.1248/cpb.35.3511

NORIAKI OHNISHI, YOSHIFUMI KIYOHARA, YOSHIAKI KITA, KOJI KURODA, TERUYOSHI YOKOYAMA

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Keywords: indomethacin, sustained-release suppository, solid dispersion, hydroxypropylmethylcellulose phthalate-polyethylene glycol matrix, molecular weight, X-ray diffraction, in vitro release rate, rectal administration, bioavailability

JOURNAL FREE ACCESS

1987 Volume 35 Issue 8 Pages 3511-3515

DOI https://doi.org/10.1248/cpb.35.3511

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Abstract

Conventional suppositories were prepared by using polyethylene glycol (PEG) alone, and sustained-release suppositories were prepared by using hydroxypropylmethylcellulose phthalate (HP55) -PEG 1000, 2000 and 4000 matrices. The effect of the molecular weight of PEG on the in vitro release characteristic and bioavailability in rabbits of indomethacin (IM) in those suppositories was investigated. The release rate of IM from the conventional and matrix suppositories decreased slightly with increase of the molecular weight of PEG. The bioavailability of the conventional suppositories was independent of the molecular weight of PEG, but the bioavailability of the matrix suppositories decreased with increase of the molecular weight of PEG.

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