DIKETOPIPERAZINE DERIVATIVES, A NEW SERIES OF PLATELET-ACTIVATING FACTOR INHIBITORS

Norihiko Shimazaki; Ichiro Shima; Keiji Hemmi; Yasuhisa Tsurumi; Masashi Hashimoto

doi:10.1248/cpb.35.3527

Chemical and Pharmaceutical Bulletin

Online ISSN : 1347-5223
Print ISSN : 0009-2363

DIKETOPIPERAZINE DERIVATIVES, A NEW SERIES OF PLATELET-ACTIVATING FACTOR INHIBITORS

Norihiko Shimazaki, Ichiro Shima, Keiji Hemmi, Yasuhisa Tsurumi, Masashi Hashimoto

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Keywords: diketopiperazine, platelet-activating factor, platelet aggregation, structure-activity relationship

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Volume 35 (1987) Issue 8 Pages 3527-3530

DOI https://doi.org/10.1248/cpb.35.3527

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Abstract

Some diketopiperazine derivatives (3a-f, 4a-f, and 5a-c) related to natural products (1 and 2) have been prepared and evaluated for their inhibition of platelet aggregation induced by platelet-activating factor (PAF).

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