An Improved Synthesis of N4-Aminocytidine

KAZUO NEGISHI; MASUMI KAWAKAMI; KIKUKO KAYASUGA; JUNICHI ODO; HIKOYA HAYATSU

doi:10.1248/cpb.35.3884

An Improved Synthesis of N⁴-Aminocytidine

KAZUO NEGISHI, MASUMI KAWAKAMI, KIKUKO KAYASUGA, JUNICHI ODO, HIKOYA HAYATSU

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Keywords: N⁴-aminocytidine, large-scale synthesis, hydrazine, bisulfite, nucleoside analog, base-pair change, mutagen, transamination, cytidine

JOURNAL FREE ACCESS

1987 Volume 35 Issue 9 Pages 3884-3887

DOI https://doi.org/10.1248/cpb.35.3884

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Abstract

N⁴-Aminocytidine, a mutagenic nucleoside, was obtained as crystals on reaction of cytidine with a reagent mixture consisting of hydrazine, bisulfite and phosphate buffer at pH 7. The product can be precipitated directly from the reaction mixture, and therefore the procedure is suitable for preparing N⁴-aminocytidine in large quantities.

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