Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Dissolution Properties of Indomethacin from Coprecipitates with Water-Insoluble Glucan
KEN MASUMOTOAKIYOSHI YOSHIDAMASAMI HIRAYAMASHIN'ICHI HAYASHIYOSHIHARU MACHIDATSUNEJI NAGAI
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1987 Volume 35 Issue 9 Pages 3940-3942

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Abstract
The dissolution properties of indomethacin (IMC) from coprecipitates with water-insoluble glucan (WIG) were investigated with a view to application of WIG to pharmaceutical preparations. WIG was produced by an enzyme present in the culture fluid of Streptococcus mutans. Coprecipitates were prepared by evaporation of the solvent from IMC solution in which WIG was suspended. The X-ray diffraction patterns indicated that the size of crystals of IMC was decreased by the coprecipitation. The dissolution rate of IMC from the coprecipitates was significantly greater than that from the physical mixture or intact IMC powder. These results indicate that WIG can improve the dissolution properties of IMC.
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© The Pharmaceutical Society of Japan
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