Synthesis and Properties of Hexanucleotides Containing Deoxyinosine

Abstract

Self-complementary hexanucleotides d(GGINCC) (N=C, A, G, T) were synthesized by the phosphotriester method. The circular dichroism (CD) spectra of these oligonucleotides showed that the oligonucleotides containing I : C or I : A pairs seem to possess a shape similar to deoxyribonucleic acid (DNA) with right-handed stacking.