Non-stereoselective Conversion of the Four Diastereoisomers at the C-24 and C-25 Positions of 3α, 7α, 12α, 24-Tetrahydroxy-5β-cholestan-26-oic Acid into Cholic Acid
キーワード:
β-oxidation
1988 年 36 巻 1 号 p. 142-145
詳細
1988 年 36 巻 1 号 p. 142-145
The four diastereoisomers at the C-24 and C-25 positions of the title compound (varanic acid) were incubated with rat liver mitochondrial fraction supplemented with adenosine triphosphate, coenzyme A, nicotinamide adenine dinucleotide, and MgCl2. All of these isomers were converted into cholic acid. Thus, the stereochemical configuration at the C-24 and C-25 positions has no significant effect on the efficiency of side chain cleavage of the tetrahydroxy acid into cholic acid.
