Acute Effect of Extract from Salviae Miltiorrhizae Radix on Renal Function in Renal Failure Rats

抄録

The acute effect of Salviae miltiorrhizae Radix extract on renal function was investigated in rats with renal failure induced by an adenine diet. Glomerular filtration rate (GFR), renal plasma flow (RPF), and renal blood flow (RBF) progressively decreased as renal impairment increased due to extended administration of adenine. Treatment with the extract significantly increased GFR by 50% in renal failure rats on the 12th d of adenine administration. The RPF in the extract-treated group also increased by 40% as compared with the control group. Similarly, Salviae miltiorrhizae Radix extract significantly increased RBF by 37%. However, the extract was ineffective in rats having renal failure with severe renal impairment, on the 24th d of adenine administration. On the other hand, the urinary excretions of urea and creatinine increased significantly by 27% and 19%, respectively, on the 12th d. These data suggest that Salviae miltiorrhizae Radix is an effective herb for the treatment of mild renal failure.