Pro-drugs for the Oral Delivery of Disodium Cromoglycate

Abstract

Bifunctional pro-drugs of disodium cromoglycate (DSCG), incorporating both lipophilic and hydrophilic pro-moieties, were desined to improve the oral absorption of DSCG, an antiallergic agent used clinically. The synthesized pro-drugs were found to prossess the desired properties for an orally active pro-drug. Among the pro-drugs tested, KY-556 (carrying twin ethyl pro-moieties and an L-lysyl pro-moiety) was particularly well absorbed orally and, as expected, displayed good antiallergic activity in the rat passive cutaneous anaphylaxis test.