Aminopyrimidines and Derivatives. XXI. : Synthesis of 5-Acyl-(4-β-D-glycopyranosylamino)pyrimidine Derivatives as Potential Anticancer Agents

抄録

Acetylation of 4-(O-acetyl-β-D-glycopyranosylamino)-6-oxo-pyrimidines (2a, d, e) with Ac₂O/pyridine at 80°C gave the 6-acetoxy derivatives 3a, d, e. Although these were also obtained by treatment with Ac₂O/H₂SO₄, prolonged reactions of 2a-c, e-f gave the 5-acetyl derivatives 4a-c, e-f. The Vilsmeier reaction of 2b-g produced the 5-formyl derivatives 5b-g, whereas 2a gave the uracil derivative 9 under similar conditions.