Evaluation of Indomethacin Sustained-Release Suppositories Prepared with a Methacrylic Acid-Methacrylic Acid Methyl Ester Copolymer-Polyethylene Glycol 2000 Solid Matrix

抄録

Indomethacin (IM) sustained-release suppositories were prepared by using a solid matrix of methacrylic acid-methacrylic acid methyl ester copolymer (Eudragit L100^[○!R] : EL) as a poorly water-soluble carrier and polyethylene glycol 2000 (PEG 2000) as a readily water-soluble carrier. The rate of IM release from EL-PEG 2000 matrix suppositories decreased with increase of the EL content. The sustained release of IM from these matrix suppositories was attributed to the development of a network structure of EL. Rectal administrations of the matrix suppositories in rabbits resulted in good characteristics for sustained release. The extent bioavailability of the 20% EL-PEG 2000 matrix suppositories (EL-20) was about 50%.