EFFECT OF SAFRAZINE, A MONOAMINE OXIDASE INHIBITOR BEARING A HYDRAZINE-TERMINAL, ON PHENYTOIN METABOLISM IN ISOLATED RAT HEPATOCYTES
キーワード:
rat liver microsome
1988 年 36 巻 1 号 p. 456-458
詳細
1988 年 36 巻 1 号 p. 456-458
The inhibitory effect of safrazine, an antidepressant monoamine oxidase inhibitor containing a hydrazine terminal, on phenytoin behavior was investigated using isolated rat hepatocytes and rat liver microsomes. Biotransformation of phenytoin to form its oxidation metabolite, 5-phenyl-5-(p-hydroxyphenyl)hydantoin, was greatly inhibited in the liver cells. Examination of microsomes showed that the inhibition mode was a mixed type.
