Studies on Peptides. CLXIV. Solution-Phase Synthesis of a 36-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Chicken Antral Peptide

LILI Guo; EIGORO MURAYAMA; SUSUMU FUNAKOSHI; NOBUTAKA FUJII; MITSURU AONO; MASAYUKI MATSUDA; MOTOYUKI MORIGA; HARUAKI YAJIMA

doi:10.1248/cpb.36.4364

LILI Guo, EIGORO MURAYAMA, SUSUMU FUNAKOSHI, NOBUTAKA FUJII, MITSURU AONO, MASAYUKI MATSUDA, MOTOYUKI MORIGA, HARUAKI YAJIMA

著者情報

キーワード: chicken antral peptide synthesis, β-cycloheptylaspartate, N^imbenzyloxymethylhistidine, N^G-mesitylenesulfonylarginine, thioanisole-mediated deprotection, hard acid deprotection, trimethylsilyl trifluoromethanesulfonate deprotection, trimethylsilyl bromide, Chou-Fasman prediction

ジャーナルフリー

1988 年 36 巻 11 号 p. 4364-4376

DOI https://doi.org/10.1248/cpb.36.4364

詳細

抄録

A 36-residue peptide amide corresponding to the entire amino acid sequence of chicken antral peptide was synthesized by assembling seven peptide fragments via the azide, followed by thioanisole-mediated deprotection with trimethylsilyl bromide and trimethylsilyl trifluoromethanesulfonate in trifluoroacetic acid.The synthetic peptide stimulated gastric secretion, but not pancreatic secretion.

責任著者(Corresponding author)

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