Synthesis of 5-Alkyl-4-oxazoleacetic Acid Derivatives with Hypolipidemic Activities

MASAHIKO SEKI; TAMON MORIYA; KAZUO MATSUMOTO; KOHKI TAKASHIMA; TETSUJI MORI; AKIO ODAWARA; SHIGEYUKI TAKEYAMA

doi:10.1248/cpb.36.4435

MASAHIKO SEKI, TAMON MORIYA, KAZUO MATSUMOTO, KOHKI TAKASHIMA, TETSUJI MORI, AKIO ODAWARA, SHIGEYUKI TAKEYAMA

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Keywords: hypolidemic agent, 5-alkyl-4-oxazoleacetic acid, hypocholesterolemic activity, hypotriglyceridemic activity, platelet aggregation inhibition, aspartic acid azlactone, Dakin-West reaction

JOURNAL FREE ACCESS

1988 Volume 36 Issue 11 Pages 4435-4440

DOI https://doi.org/10.1248/cpb.36.4435

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Abstract

A series of 2-aryl and 2-alkyl derivatives of 5-alkyl-4-oxazoleacetic acids was synthesized and tested for hypolipidemic activity. Among them, 5-isopropyl-2-(4-fluorophenyl)-4-oxazoleacetates exhibited potent activities, being more active than clofibrate [ethyl 2-(4-chlorophenoxy) isobutvrate].

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