抄録
A series of [2-[p-(un) substituted phenyl] imidazo [2, 1-b] benzothiazol-3-yl] acetic acid derivativeswas prepared.The 2-[p-(un) substituted phenyl]imidazo [2, 1-b] benzothiazoles (2a-e) were firstconverted to the corresponding 3-(dimethylaminomethyl) Mannich bases (3a-e), which in turnwere converted to the methiodide salts (4a-d) and thence to the desired products (7a-e), (see Chart 1).
Some of the acetic acid derivatives (7a, c, d) were tested for analgesic and antiinflammatoryactivities by means of carrageenin-induced paw edema, streching induced by acetic acid andcapillary permeability inhibition assays.
