Reaction of Thio Acid S-Esters with p-Toluenesulfonic Acid : A Facile Gynthesis of p-Toluenethiosulfonic S-Esters

Abstract

Treament of dehydrated p-toluensulfonic acid (TsOH) with thio acid S-esters such as carbothioic acid and phosphorus thio acid S-esters in refluxing solvent resulted in the formation of p-toluenethiosulfonic S-esters (TsSR). The reaction of trialkyl phosphorotrithioites with TsOH provided the corresponding TsSR in relatively good yields. This constitutes a new and facile method for the preparation of unsymmetrical thiosulfonic S-esters.