A Convenient Synthesis of 9-(2-Hydroxyethoxymethyl)guanine (Acyclovir) and Related Compounds

HIROATSU MATSUMOTO; CHISATO KANEKO; KEIKO YAMADA; TADAO TAKEUCHI; TAKEO MORI; YOSHIHISA MIZUNO

doi:10.1248/cpb.36.1153

HIROATSU MATSUMOTO, CHISATO KANEKO, KEIKO YAMADA, TADAO TAKEUCHI, TAKEO MORI, YOSHIHISA MIZUNO

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Keywords: antiherpetic agnet

JOURNAL FREE ACCESS

1988 Volume 36 Issue 3 Pages 1153-1157

DOI https://doi.org/10.1248/cpb.36.1153

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Abstract

A convenient and economical synthesis of 9-(2-hydroxyethoxymethyl)guanine (1, acyclovir, Zovirax, or acyclic guanosine : an antiherpetic agent)from guanine was developed via N², O-diacetylacyclovir. Two closely related compounds, N²-acetylacyclovir (7) and O-acetylacyclovir (8), were also prepared by selective deacetylation.

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