Extra-weak Chemiluminescence of Drugs. VII. : A Possible Pathway of Chemiluminescence Generation from Imipramine Hydrochloride Produced by Autoxidation
キーワード:
imipramine peroxy radical
1988 年 36 巻 4 号 p. 1469-1474
詳細
1988 年 36 巻 4 号 p. 1469-1474
Many tricyclic antidepressant drugs such as imipramine hydrochloride showed high extraweak chemiluminescence (CL) with similar emission spectra. Iminodibenzyl and N-methylimino-dibenzyl, compounds saturated at the 10-11 bond, generated high CL, whereas iminostibene, a compound unsaturated at the 10-11 bond, did not. Mechanisms of CL produced by autoxidation of imipramine hydrochloride were investigated. The existence of the imipramine radical and the imipramine peroxy radical during the autoxidation were supported by an electron spin resonance study. A possible pathway is proposed for CL generation from imipramine hydrochloride by autoxidation.
