Carbon-13 Nuclear Magnetic Resonance Study of meso-Hexestrol and Its Derivatives

抄録

The carbon-13 unclear magnetic resonance chemical shift assignments for meso-hexestrol (1a), made on the basis of two-dimensional ¹³-¹H chemical shift correlation, long-range selective ¹H decoupling experiment, and a reported two-dimensional Fourier-trasform experiment for long-range proton-carbon-13 spin coupling constants, are reported. For measurement of carbon-protoncoupling constants of meso-hyxestrol derivatives (1b-e, 2a-d, 3a-c, and 4), the coupling informaiton was detected by using a gated decoupling facility which permitted retention of the nuclear Overhauser enhancement and a long-range selective ¹H decoupling experiment. The results showed that the aromatic carbon resonances are influenced by the structure (no double bond, or one or two double bond(s)) of the hexane framework in the central portion.