Synthesis and Antiulcer Activity of (Isochroman-1-yl)alkylamines. I

Abstract

N-benzyl-2-(isochroman-1-yl)-1-methylethylamine (6f), prepared by the reaction of 1-ethoxy-isochroman (4) and acetone followed by reductive amination, was found to possess inhibitory activity against aspirin-induced ulcer but did not exhibit gastric antisecretory activity. Structural modification of 6f was undertaken and the structure-activity relationships of the derivatives are discussed.