INTERCONVERSION MODEL ANALYSIS AND ESTIMATION OF AVAILABLE FRACTIONS FOR 4-ACETAMINOBENZALDEHYDE AND ITS REVERSIBLE METABOLITE, 4-ACETAMINOBENZYLALCOHOL, IN THE RAT USING THE MULTI-LINES FITTING TECHNIQUE

Abstract

An interconversion model which incorporated a first-pass metabolism was applied to the disposition kinetics of 4-acetaminobenzaldehyde (AB) and its reversible metabolite, 4-acetaminobenzylalcohol (ABA) in the rat. The rates of available fraction of AB, F_H1, and of the sequential available fraction of ABA, F_H2, were estimated by application of the computer multi-lines fitting technique.