1988 年 36 巻 5 号 p. 1922-1925
An interconversion model which incorporated a first-pass metabolism was applied to the disposition kinetics of 4-acetaminobenzaldehyde (AB) and its reversible metabolite, 4-acetaminobenzylalcohol (ABA) in the rat. The rates of available fraction of AB, FH1, and of the sequential available fraction of ABA, FH2, were estimated by application of the computer multi-lines fitting technique.