Site-Selectivity in the Reaction of 3-Substituted Pyridine 1-Oxides with Phosphoryl Chloride
キーワード:
chlorination
1988 年 36 巻 6 号 p. 2244-2247
詳細
1988 年 36 巻 6 号 p. 2244-2247
Site-selectivity in the reaction of 3-substituted pyridine 1-oxide with phosphoryl chloride was investigated. When a strongly electron-withdrawing group (e.g. CN, CONRR', COOR, or NO2) was substituted at the 3-position, the reaction of 3-substituted pyridine 1-oxides with phosphoryl chloride yielded 3-substituted 2-chloropyridines as the main products.
