Studies on Positive Inotropic Agents. VI. : Synthesis of 1-Aromatic Ring Substituted 4-(3, 4-Dimethoxybenzoyl)-piperazine Derivatives

HIDENORI OGAWA; SHIGEHARU TAMADA; TAKAFUMI FUJIOKA; SHUJI TERAMONO; KAZUMI KONDO; SHUJI YAMASHITA; YOUICHI YABUUCHI; MICHIAKI TOMINAGA; KAZUYUKI NAKAGAWA

doi:10.1248/cpb.36.2401

HIDENORI OGAWA, SHIGEHARU TAMADA, TAKAFUMI FUJIOKA, SHUJI TERAMONO, KAZUMI KONDO, SHUJI YAMASHITA, YOUICHI YABUUCHI, MICHIAKI TOMINAGA, KAZUYUKI NAKAGAWA

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Keywords: 1-aromatic ring substituted 4-(3, 4-dimethoxybenzoyl)piperazine derivative

JOURNAL FREE ACCESS

1988 Volume 36 Issue 7 Pages 2401-2409

DOI https://doi.org/10.1248/cpb.36.2401

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Abstract

A series of 1-aromatic ring substituted 4-(3, 4-dimethoxybenzoyl)piperazines were synthesized and examined for positive inotropic activity on the canine heart. Among them, 6-[4-(3, 4-dimethoxybenzoyl)-1-piperazinyl]-3-methyl-1H, 3H-quinazolin-2, 4-dione was found to have a potent activity.

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