Intestinal Absorption of N, N'-Dimethylcarbamoylmethyl 4-(4-Guanidinobenzoyloxy) Phenylacetate Methanesulfonate in Rats

Abstract

The intestinal absorption of N, N'-dimethylcarbamoylmethyl 4-(4-guanidnobenzoyloxy) phenylacetate methanesulfonate (FOY305^[○!R]) in rats was investigated using a rat intestinal loop method. Plasma drug concentrations and the disappearance of the drug from the intestinal lumen were measured. The absorption of FOY305 after administration into a rectal loop was greater than those after administration into variously positioned small intestinal loops. The low absorption of FOY305 after administration into the small intstine was due to the rapid degradation of FOY305 by esterase activity in the small intestinal lumen.