抄録
The antitumor effect of aclarubicin (ACR) in an oily dosage formulation composed of Lipiodol (lymphographic oil), or with linoleic acid and 1-dodecylazacycloheptan-2-one (Azone), was investigated by hepatic intra-arterial administration against Walker 256 carcinosarcoma implanted in the rat liver. Evaluation based on the grown rate of the tumor indicated that ACR was more effective on administration as Lipiodol solution or oil-in-water emulsion compared to saline aolution, but the addition of linoleic acid or Azone to Lipiodol solution did not further improve the antitumor activity of ACR. A clear correlation between the depression of the hepatic tumor growth rate and the levels of ACR and its active metabolites in the tumor tissue 24h after the hepatic intra-arterial administration was also observed.
