Isolation ofDillapiol from a Chemotype of Perilla frutescencs as an Active Principle for Prolonging Hexobarbital-Induced Sleep

Abstract

The effects of MeOH extracts from six distinct chemotypes of Perilla frutescens, which differ in the main components of the essential oils, on the prolongation of hexobarbital-induced sleep in mice were examined. Dillapiol, 1-allyl-2, 3-dimethoxyl-4, 5-(methylenedioxy)-benzene, was isolated from the MeOH extract of the chemotype PP-DM as an active principe (ED₅₀=1.57 mg/kg).