Author's Organization：Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Josai University
Trans-4-methylcyclohexylamine was found to inhibit pig spermidine synthase potently in assay conditions containing 50 μM of decarboxylated S-adenosylmethionine. It showed 50% inhibition at 1.7 μM compared to 8.1 μM for cyclohexylamine, and 2.5 μM for S-adenosyl-1, 8-diamino-3-thiooctane, known as the most potent inhibitor. The inhibition was competitive with putrescine, similar to cyclohexylamine, and the Ki was 40 nM.
