Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
New Water-Soluble Fluorogenic Amine. : 7-Aminocoumarin-4-methanesulfonic Acid (ACMS) and Related Substrates for Proteinases
EISUKE SATO, AKIRA MATSUHISA, MARI SAKASHITA, YUICHI KANAOKA
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Keywords: kinetic study
JOURNAL FREE ACCESS

1988 Volume 36 Issue 9 Pages 3496-3502

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Abstract
The synthesis and properties of a water-soluble fluorogenic amine, 7-aminocoumarin-4-methanesulfonic acid (ACMS, 5) are described. Several peptide amides of 5 were synthesized and examined as new fluorogenic substrates for chymotrypsin, trypsin and related enzymes.
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© The Pharmaceutical Society of Japan
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