Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
A NEW SYNTHESIS OF EUPOLAURAMINE FROM A BENZ [f] INDOLE DERIVATIVE
村上 泰興渡辺 敏子酒井 正博横山 祐作
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キーワード: cyclization
ジャーナル フリー

1988 年 36 巻 9 号 p. 3732-3735

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抄録
Eupolauramine (1__-), a structurally unique alkaloid having oxindole and pyridine nuclei, was synthesized from a benz [f] indole derivative easily prepared from a pyrrole derivative. The synthetic route involves one-pot cnstruction of a pyridine ring via an enediamine moiety derived from the corresponding indole-2-carboxylic acid, and transformation of the enediamine to oxindole.
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© The Pharmaceutical Society of Japan
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