Novel Fluorogenic Substrates Containing Bimane System for Microdetermination of Angiotensin I Converting Enzyme
1989 年 37 巻 1 号 p. 145-147
詳細
1989 年 37 巻 1 号 p. 145-147
As a sensitive fluorometric assay for the activity of angiotensin converting enzyme, bimane-peptides containing tryptophan, i.e., 1, 7-dioxo-2, 5, 6-trimethyl-1H, 7H, pyrazolo[1, 2-α]pyrazol-3-yl-methylthiomethylcarbonyl-glycyl (or L-phenylalanyl)-L-tryptophyl-L-leucine (or L-proline), were synthesized and shown to be potent fluorogenic substrates for the micro-determination of angiotensin I converting enzyme activity.
