Spectroscopic Analysis of Charge Transfer Complex Formation between Neuroleptics and Iodine

Abstract

Molecular interactions between iodine and various neuroleptics were investigated by UV/Vis spectroscopy. Iodine was found to form charge transfer complexes in a 1 : 1 stoichiometry and of n-σ type with these molecules. The values of the formation constants K_c of these iodinated complexes indicate a strong donor-acceptor interaction. These drugs can therefore be expected to interfere with thyroid metabolism.