Synthesis and Antiucler Activity of the Metabolites of 2-(4-Ethyl-1-piperazinyl)-4-phenylquinoline Dimaleate(AS-2646), a Novel Gastric Antisecretory and Antiulcer Agent

Katsuhiko HINO; Katsuyoshi KAWASHIMA; Makoto OKA; Hitoshi UNO; Jun-ichi MATSUMOTO

doi:10.1248/cpb.37.190

Katsuhiko HINO, Katsuyoshi KAWASHIMA, Makoto OKA, Hitoshi UNO, Jun-ichi MATSUMOTO

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Keywords: 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline

JOURNAL FREE ACCESS

1989 Volume 37 Issue 1 Pages 190-192

DOI https://doi.org/10.1248/cpb.37.190

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Abstract

The metabolites 3 and 4 of 2-(4-ethyl-1-piperazinyl)-4-phenylquinoline dimaleate (AS-2646, 1), a candidate as a gastric antisecretory and antiulcer drug, were synthesized to confirm thr proposed structures. The effects of the metabolites 2-4 on ulcer induced by stress were determined.

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