Regioselective Syntheses of Substituted Thioxanthen- and Selenoxanthen-9-one Derivatives

Abstract

Various methoxy-substituted thioxanthen-9-one derivatives were regioselectively synthesized by a one-pot condensation of S-lithiated thiosalicylic ester or amides, obtained via directed lithiation of tertiary benzamides, with benzynes. Similarly, the synthesis of selenoxanthen-9-ones was achieved.