Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Synthetic Studies on Spirovetivane Phytoalexins. IV. : A Stereoselective Synthesis of (±)-3-Hydroxysolavetivone
岩田 宙造竹本 佳司中村 文胤今西 武
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1989 年 37 巻 10 号 p. 2643-2646

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Oxidation of the silyl enol ether of (2RS, 5RS, 10RS)-6, 10-dimethyl-2-pivaloyloxyspiro[4.5]dec-6-en-8-one (5) with triphenyl phosphite ozonide (TPPO) gave stereoselectively the C9-hydroxylated derivative (6a), which was transformed into a spirovetivane phytoalexin, (±)-3-hydroxysolavetivone (1), by a several-step sequence.
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© The Pharmaceutical Society of Japan
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