Synthese et Etude Pharmacologique de Pyridazino[4, 5-b]carbazoles

Henriette LANDELLE; Daniel LADUREE; Michel CUGNON DE SEVRICOURT; Max ROBBA

doi:10.1248/cpb.37.2679

Henriette LANDELLE, Daniel LADUREE, Michel CUGNON DE SEVRICOURT, Max ROBBA

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Keywords: carbazole, pyridazino[4, 5-b]carbazole, cyclization, chlorodehydroxylation, nucleophilic substitution, cytotoxic activity

JOURNAL FREE ACCESS

1989 Volume 37 Issue 10 Pages 2679-2682

DOI https://doi.org/10.1248/cpb.37.2679

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Abstract

Cyclization reaction of hydrazine with carbazole-2, 3-methyl dicarboxylates gave 1, 4-dioxo-1, 2, 3, 4-tetrahydropyridazino[4, 5-b]carbazoles. Chlorodehydroxylation provided 1, 4-dichloropyridazino[4, 5-b]carbazoles and nucleophilic substitution gave 1, 4-dialkoxy pyridazino[4, 5-b]carbazoles. These compounds were tested for cytotoxic activity against L1210 leukemia in mice.

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