Studies on Pyrimidine Derivatives. XLI. : Palladium-Catalyzed Cross-Coupling Reaction of Halopyrimidines with Aryl- and Vinyltributylstannanes

Yoshinori KONDO; Ryo WATANABE; Takao SAKAMOTO; Hiroshi YAMANAKA

doi:10.1248/cpb.37.2814

Yoshinori KONDO, Ryo WATANABE, Takao SAKAMOTO, Hiroshi YAMANAKA

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Keywords: palladium catalyzed reaction, halopyrimidine, aryltributylstannane, vinyltributylstannane, arylpyrimidine, vinyl-pyrimidine, site-selectivity

JOURNAL FREE ACCESS

1989 Volume 37 Issue 10 Pages 2814-2816

DOI https://doi.org/10.1248/cpb.37.2814

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Abstract

The arylation of 2-, 4-, and 5-halopyrimidines with aryltributylstannanes in the presence of dichlorobis-(triphenylphosphine)palladium was investigated with successful results. The reaction can be expanded to the synthesis of 2-, 4-, and 5-vinylpyrimidines with generality. The site-selectivity of the reaction for 4, 5-dihalopyrimidines is also described.

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