Antitumor Agents. III. : A Novel Procedure for Inversion of the Configuration of a Tertiary Alcohol Related to Camptothecin
1989 年 37 巻 12 号 p. 3382-3385
詳細
1989 年 37 巻 12 号 p. 3382-3385
As part of our attempts to employ the unnatural (R)-type compound (8), which was produced by optical resolution of the pyranoindolizine 6, in the synthesis of natural (20S)-camptothecin, inversion of the configuration at the tertiary alcohol of the (4R)-pyranoindolizine 11 to give the (4S)-isomer 14 was achieved in 33% yield via the methanesulfonate 12.
