Studies on Hypolipidemic Agents. IV. : 3-[4-(Phenylthio)benzoyl]propionic Acid Derivatives

Kazuya KAMEO; Yumiko ASAMI; Kunio OGAWA; Tohru MATSUNAGA; Shiuji SAITO; Kazuyuki TOMISAWA; Kaoru SOTA

doi:10.1248/cpb.37.1260

Kazuya KAMEO, Yumiko ASAMI, Kunio OGAWA, Tohru MATSUNAGA, Shiuji SAITO, Kazuyuki TOMISAWA, Kaoru SOTA

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Keywords: 3-[4-(phenylthio)benzoyl]propionic acid, 2-acetylthio-3-[4-(4-chlorophenoxy)benzoyl]propionic acid, hypolipidemic activity, structure-activity relationship, clofibrate

JOURNAL FREE ACCESS

1989 Volume 37 Issue 5 Pages 1260-1267

DOI https://doi.org/10.1248/cpb.37.1260

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Abstract

2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propionic acid (10) and its derivatives seemed to have the most potent hypocholesterolemic activities. Compound 10 showed strong activity, especially in cholesterol-fed rats.

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