An Improved Optical Resolution of 3-Acetylthio-2-methylpropionic Acid by Use of a New Chiral Amine, N-Isopropyl(phenylalaninol)

Tadahiro SAWAYAMA; Masatoshi TSUKAMOTO; Takashi SASAGAWA; Shunsuke NARUTO; Jun-ichi MATSUMOTO; Hitoshi UNO

doi:10.1248/cpb.37.1382

澤山忠弘, 塚本正利, 笹川隆, 成戸俊介, 松本純一, 宇野準

著者情報

キーワード: angiotensin converting enzyme inhibitor, resolving agent, ternary phase diagram, eutectic composition

ジャーナルフリー

1989 年 37 巻 5 号 p. 1382-1383

DOI https://doi.org/10.1248/cpb.37.1382

詳細

抄録

(S)-3-Acetylthio-2-methylpropionic acid was obtained in a good yield by an effective optical resolution with a newly synthesized chiral amine, (S)-N-isopropyl(phenylalaninol), which was readily derived from (S)-phenylalaninol, as a resolving agent.

責任著者(Corresponding author)

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