Synthesis of 1, 5-Disubstituted Imidazoles Including an Imidazole Analogue of Prostaglandin from 4(5)-Hydroxymethylimidazole

抄録

1-(6-Carboxyhexyl)-5-[(E)-3-hydroxy-1-octenyl]midazole, an imidazole analogue of prostaglandin, was synthesized from 4(5)-hydroxymethylimidazole hydrochloride. The key step involves regioselective alkylation of 4(5)-tertbutyldimethylsilyloxymethylimidazole to give predominantly 1, 5-disubstituted imidazole.