Synthese des Dihydro-6, 11 5H-pyrimidino[4, 5-a]carbazoles et de 11H-Pyrimidino[4, 5-a]carbazoles

Abstract

The synthesis of 6, 11-dihydro-5H-pyrimidino[4, 5-a]carbazoles (10) was achieved by cyclization of 1, 2, 3, 4-tetrahydrocarbazol-1-ones with triformamidomethene. The oxidation with potassium permenganate or mangenese bioxide of 6, 11-dihydro-5H-pyrimidino[4, 5-a]carbazoles gave the 11 H-pyrimidino[4, 5-a]carbazoles (11). The reactions of the pyrimidinocarbazole (11a) with organolithium compounds afforded 4-substituted derivatives (20, 21). The structure of the derivatives was determined by proton nuclear magnetic resonance.