Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
One-Step Preparation of D-Penicillamine from Benzylpenicillin
Toshihisa OGAWA, Kazuyuki TOMISAWA, Kaoru SOTA
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Keywords: D-penicillamine, benzylpenicillin, benzylpenicilloic acid α-amide, arylamine, ring fission
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1989 Volume 37 Issue 6 Pages 1609-1611

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Abstract
The preparation of D-penicillamine (5) was achieved by a single-step reaction of benzylpenicillin potassium salt (1) with arylamines (2, 7, and 13). The intermediates in these reactions should be the penicilloic acid α-amides. The structures of by-products formed in these reactions were also determined.
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© The Pharmaceutical Society of Japan
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