Structure and Activity of New Deodorant Biphenyl Compounds from Thyme (Thymus vulgaris L.)

Kayoko MIURA; Takashi INAGAKI; Nobuji NAKATANI

doi:10.1248/cpb.37.1816

Kayoko MIURA, Takashi INAGAKI, Nobuji NAKATANI

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Keywords: thyme, deodorant activity, Thymus vulgaris L, Labiatae, 3, 4, 3', 4'-tetrahydroxy-5, 5'-diisopropyl-2, 2'-dimethylbiphenyl, 3, 4, 4'-trihydroxy-5, 5'-diisopropyl-2, 2'-dimethylbiphenyl, methyl mercaptan, spice, biphenyl

JOURNAL FREE ACCESS

1989 Volume 37 Issue 7 Pages 1816-1819

DOI https://doi.org/10.1248/cpb.37.1816

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Abstract

Two new biphenyls, 3, 4, 3', 4'-tetrahydroxy-5, 5'-diisopropyl-2, 2'-dimethylbiphenyl (4a) and 3, 4, 4'-trihydroxy-5, 5'-diisopropyl-2, 2'-dimethylbiphenyl (5), were isolated from the leaves of thyme (Thymus vulgaris L.). Their structures were elucidated by spectroscopic methods and chemical transformations. Both biphenyls 4a and 5 showed more effective deodorant activity against methyl mercaptan than did rosmanol, carnosol or sodium copper chlorophylline.

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