Synthesis of Entadamide A and Entadamide B Isolated from Entada phaseoloides and Their Inhibitory Effects on 5-Lipoxygenase

Fumio IKEGAMI; Toshikazu SEKINE; Masaki ABURADA; Yuichi FUJII; Yasuhiro KOMATSU; Isamu MURAKOSHI

doi:10.1248/cpb.37.1932

池上文雄, 関根利一, 油田正樹, 藤井祐一, 小松靖弘, 村越勇

著者情報

キーワード: synthesis, sulfur-containing amide, lipoxygenase inhibitor, trans-N-(2-hydroxyethyl)-3-methylthiopropenamide, N-(2-hydroxyethyl)-3, 3-bis(methylthio)propanamide, entadamide A, entadamide B, Entada phaseoloides, Leguminosae

ジャーナルフリー

1989 年 37 巻 7 号 p. 1932-1933

DOI https://doi.org/10.1248/cpb.37.1932

詳細

抄録

Two new sulfur-containing amides, entadamide A (1) and entadamide B (2), isolated from the seeds of Entada phaseoloides, were synthesized by the addition reaction of methanethiol to propiolic acid (5) followed by condensation with ethanolamine by the use of dicyclohexylcarbadiimide. These compounds inhibited the 5-lipoxygenase activity of RBL-1 cells at 10^-4 g/ml. This finding suggests that entadamides A and B may be examples of a new type of anti-inflammatory drug.

責任著者(Corresponding author)

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