Asymmetric Synthesis of 2-Substituted-3-aminocarbonyl Propionic Acid

Takahide NISHI; Mitsuya SAKURAI; Sadao SATO; Mitsuru KATAOKA; Yasuhiro MORISAWA

doi:10.1248/cpb.37.2200

Takahide NISHI, Mitsuya SAKURAI, Sadao SATO, Mitsuru KATAOKA, Yasuhiro MORISAWA

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Keywords: 2-substituted-3-aminocarbonyl propionic acid, N-terminal element, renin inhibitor, oxazolidinone, diastereoselective alkylation

JOURNAL FREE ACCESS

1989 Volume 37 Issue 8 Pages 2200-2203

DOI https://doi.org/10.1248/cpb.37.2200

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Abstract

An asymmetric synthetic route to 2-substituted-3-aminocarbonyl propionic acid, which is the significant component of low-molecular-weight renin inhibitors, is described. The key step of this synthesis is diastereoselective alkylation by using chiral oxazolidinone and benzyl bromoacetate.

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