Hematological Studies on Naturally Occurring Substances. II. : Effects of Animal Crude Drugs on Blood Coagulation and Fibrinolysis Systems

Jen Der WANG; Takao NARUI; Hideaki KURATA; Kouichi TAKEUCHI; Takao HASHIMOTO; Toru OKUYAMA

doi:10.1248/cpb.37.2236

王正徳, 成井孝雄, 倉田英明, 竹内幸一, 橋本孝雄, 奥山徹

著者情報

キーワード: animal crude drug, Cervi Cauda, Hirudi, blood coagulation accelerator, coagulation inhibitor, fibrinolysis accelerator, fibrinolysis inhibitor, plasma recalcification time method, fibrin plate method

ジャーナルフリー

1989 年 37 巻 8 号 p. 2236-2238

DOI https://doi.org/10.1248/cpb.37.2236

詳細

抄録

The effects of 112 extracts prepared from 37 kinds of animal crude drugs and a dog's filaria were investigated on the blood coagulation and fibrinolysis systems in vitro. The plasma recalcification time method was employed for the assay of blood coagulation and fibrinolytic activity was tested by the fibrin plate method. It was found that the water extracts of Bombyx Batryticatus, Carpio Fel and Holotrichiae Vermiculus showed potent inhibitory effects on blood coagulation. The methanol extracts of Phocae Thstis et Penis, Scorpion and Tabanus were promotive effect, on the other hand. As regards the fibrinolysis system, the water extracts of Agkistrodon, Lumbricus, Hirudo, Scolopendra and Scorpion and the methanol extract of Hirudo showed a remarkable activity.

責任著者(Corresponding author)

J-STAGEへの登録はこちら（無料）